netb, a pore-forming toxin from necrotic enteritis strains of clostridium perfringensnetb,造孔坏死性肠炎perfringens梭状芽胞杆菌菌株的毒素.pdfVIP

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netb, a pore-forming toxin from necrotic enteritis strains of clostridium perfringensnetb,造孔坏死性肠炎perfringens梭状芽胞杆菌菌株的毒素.pdf

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netb, a pore-forming toxin from necrotic enteritis strains of clostridium perfringensnetb,造孔坏死性肠炎perfringens梭状芽胞杆菌菌株的毒素

Toxins 2010, 2, 1913-1927; doi:10.3390/toxins2071913 OPEN ACCESS toxins ISSN 2072-6651 /journal/toxins Review NetB, a Pore-Forming Toxin from Necrotic Enteritis Strains of Clostridium perfringens Anthony L. Keyburn 1, Trudi L. Bannam 2, Robert J. Moore 1,2 and Julian I. Rood 2,* 1 CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia; E-Mail: Anthony.Keyburn@csiro.au (A.K.) 2 Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Victoria 3800, Australia; E-Mails: trudi.bannam@ (T.L.B.); Rob.Moore@csiro.au (R.J.M.) * Author to whom correspondence should be addressed; E-Mail: julian.rood@; Tel.: +61-3-9902-9157; Fax: +61-3-9902-9222. Received: 22 June 2010; in revised form: 9 July 2010 / Accepted: 22 July 2010 / Published: 23 July 2010 Abstract: The Clostridium perfringens necrotic enteritis B-like toxin (NetB) is a recently discovered member of the β-barrel pore-forming toxin family and is produced by a subset of avian C. perfringens type A strains. NetB is cytotoxic for avian cells and is associated with avian necrotic enteritis. This review examines the current state of knowledge of NetB : its role in pathogenesis, its distribution and expression in C. perfringens and its vaccine potential. Keywords: NetB; necrotic enteritis; Clostridium perfringens; pore-forming toxin 1. Introduction C. perfringens is a Gram-positive anaerobe and is ubiquitous in the environm