原创力文档new quinoxaline derivatives as potential mt1 and mt2 receptor ligands新喹喔啉衍生物潜在mt1和是受体配体.pdfVIP
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new quinoxaline derivatives as potential mt1 and mt2 receptor ligands新喹喔啉衍生物潜在mt1和是受体配体
Molecules 2012, 17, 7737-7757; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
New Quinoxaline Derivatives as Potential MT and MT
1 2
Receptor Ligands
Saioa Ancizu 1, Nerea Castrillo 1, Silvia Pérez-Silanes 1, Ignacio Aldana 1, Antonio Monge 1,
Philippe Delagrange 2, Daniel-Henry Caignard 2 and Silvia Galiano 1,*
1 Unidad en Investigación y Desarrollo de Medicamentos, Centro de Investigación en Farmacobiología
Aplicada (CIFA), Universidad de Navarra, C/Irunlarrea, 1, 31008 Pamplona, Spain;
E-Mails: sancizupere@alumni.unav.es (S.A.); ncastrillo@alumni.unav.es (N.C.);
sperez@unav.es (S.P.-S.); ialdana@unav.es (I.A.); amonge@unav.es (A.M.)
2 IdRServier, 125 Chemin de ronde, 78290 Croissy-sur-Seine, France;
E-Mails: philippe.delagrange@ (P.D.); daniel-henri.caignard@ (D.-H.C.)
* Author to whom correspondence should be addressed; E-Mail: sgaliano@unav.es;
Tel.: +34-948-425-653; Fax: +34-948-425-652.
Received: 17 April 2012; in revised form: 14 June 2012 / Accepted: 18 June 2012 /
Published: 25 June 2012
Abstract: Ever since the idea arose that melatonin might promote sleep and resynchronize
circadian rhythms, many research groups have centered their efforts on obtaining new
melatonin receptor ligands whose pharmacophores include an aliphatic chain of variable
length united to an N-alkylamide and a methoxy group (or a bioisostere), linked to a central
ring. Su
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