原创力文档nonlinear observer output-feedback mpc treatment scheduling for hiv非线性观测器输出反馈mpc调度艾滋病毒治疗.pdfVIP
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nonlinear observer output-feedback mpc treatment scheduling for hiv非线性观测器输出反馈mpc调度艾滋病毒治疗
Zurakowski BioMedical Engineering OnLine 2011, 10:40
/content/10/1/40
RESEARCH Open Access
Nonlinear observer output-feedback MPC
treatment scheduling for HIV
Ryan Zurakowski
Correspondence: ryanz@ Abstract
Department of Electrical and
Computer Engineering, University Background: Mathematical models of the immune response to the Human
of Delaware, Newark, DE 19716,
USA Immunodeficiency Virus demonstrate the potential for dynamic schedules of Highly
Active Anti-Retroviral Therapy to enhance Cytotoxic Lymphocyte-mediated control of
HIV infection.
Methods: In previous work we have developed a model predictive control (MPC)
based method for determining optimal treatment interruption schedules for this
purpose. In this paper, we introduce a nonlinear observer for the HIV-immune
response system and an integrated output-feedback MPC approach for
implementing the treatment interruption scheduling algorithm using the easily
available viral load measurements. We use Monte-Carlo approaches to test
robustness of the algorithm.
Results: The nonlinear observer shows robust state tracking while preserving state
positivity both for continuous and discrete measurements. The integrated output-
feedback MPC algorithm stabilizes the desired steady-state. Monte-Carlo testing
shows significant robustness to modeling error, wit
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