原创力文档neuroprotective properties of melissa officinalis after hypoxic-ischemic injury both in vitro and in vivo神经保护的性质梅丽莎缺氧缺血性脑损伤后在体外及体内.pdfVIP
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neuroprotective properties of melissa officinalis after hypoxic-ischemic injury both in vitro and in vivo神经保护的性质梅丽莎缺氧缺血性脑损伤后在体外及体内
Bayat et al. DARU Journal of Pharmaceutical Sciences 2012, 20:42
/content/20/1/42
RESEARCH ARTICLE Open Access
Neuroprotective properties of Melissa officinalis
after hypoxic-ischemic injury both in vitro
and in vivo
1 2 3 1
Mohammad Bayat , Abolfazl Azami Tameh , Mohammad Hossein Ghahremani , Mohammad Akbari ,
4 5 1,6*
Shahram Ejtemaei Mehr , Mahnaz Khanavi and Gholamreza Hassanzadeh
Abstract
Background: Brain ischemia initiates several metabolic events leading to neuronal death. These events mediate
large amount of damage that arises after some neurodegenerative disorders as well as transient brain ischemia.
Melissa officinalis is considered as a helpful herbal plant in the prevention of various neurological diseases like
Alzheimer that is related with oxidative stress.
Methods: We examined the effect of Melissa officinalis on hypoxia induced neuronal death in a cortical neuronal
culture system as in vitro model and transient hippocampal ischemia as in vivo model. Transient hippocampal
ischemia was induced in male rats by tow vessel-occlusion for 20 min. After reperfusion, the histopathological
changes and the levels inflammation, oxidative stress status, and caspase-3 activity in hippocampus were measured.
Results: Cytotoxicity assays showed a significant protection of a 10 μg/ml dose of Melissa against hypoxia in
cultured neurons which was confirmed by a conventional staining (P0.05). Melissa treatment decrease caspase3
activity (P0.05) and TUNEL-positive cells significantly (P0.01). Melissa oil has also inhibited malon dialdehyde level
and attenuated decrease of Antioxidant Capacity in the h
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