原创力文档neuroprotective effects of ginsenosides rh1 and rg2 on neuronal cells神经保护作用的皂苷含量rh1和rg2神经元细胞.pdfVIP
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neuroprotective effects of ginsenosides rh1 and rg2 on neuronal cells神经保护作用的皂苷含量rh1和rg2神经元细胞
Li et al. Chinese Medicine 2011, 6:19
/content/6/1/19
RESEARCH Open Access
Neuroprotective effects of ginsenosides Rh1 and
Rg2 on neuronal cells
1 1 2 1*
Xiao-Fan Li , Cathy Nga-Ping Lui , Zhi-Hong Jiang and Yung Kin-Lam Ken
Abstract
Background: The present study investigates the effects of ginsenosides Rh 1 and Rg2 against 6-hydroxydopamine
(6-OHDA), a neurotoxin on SH-SY5Y cells and PC-12 cells. The effects of these two ginsenosides on neuronal
differentiation are also examined.
Methods: LDH assay was used to measure cell viability after exposure to 6-OHDA and ginsenosides. Neuronal
differentiation was evaluated by changes in cell morphology and density of neurite outgrowths. Western blotting
was used to determine the ginsenosides’ effects on activation of extracellular signal-regulated protein kinases (ERKs).
Results: Rh1 and Rg2 attenuated 6-OHDA toxicity in SH-SY5Y cells and induced neurite outgrowths in PC-12 cells.
6-OHDA-induced ERK phosphorylation was decreased by Rh and Rg . 20(R)-form and 20(S)-form of the
1 2
ginsenosides exerted similar effects in inducing neurite outgrowths in PC-12 cells.
Conclusion: The present study demonstrates neuroprotective effects of ginsenosides Rh 1 and Rg2 on neuronal cell
lines. These results suggest potential Chinese medicine treatment for neurodegenerative disorders (eg Parkinson’s
disease).
Background and c-jun N-terminal kinase (JNK) activation have been
Parkinson’s disease (PD) is a common motor system disor- observed in various models [8-10].
der characterized clinically by rig
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