new 1,2,3-selenadiazole and 1,2,3-thiadiazole derivatives新1、2、3-selenadiazole和1,2,3-thiadiazole衍生品.pdfVIP

Molecules 2004, 9, 957-967 molecules ISSN 1420-3049 New 1,2,3-Selenadiazole and 1,2,3-Thiadiazole Derivatives Mousa Al-Smadi * and Samer Ratrout Department of Applied Chemical Science, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan * Author to whom correspondence should be addressed; e-mail: mariam10@.jo Received: 13 July 2004 / Accepted: 9 September 2004 / Published: 30 November 2004 Abstract: New 1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives, 14-23, were prepared from the ketones 1-5 via the corresponding semicarbazones or hydrazones 6-12. The Hurd-Mori and Lalezari methods were used, respectively, for the preparation of these 1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives. The intermediate 13 was also trapped, separated and fully characterized. These derivatives are important for photocrosslinking processes and due to their potential biological activity. Keywords: Semicarbazone, hydrazone, ferrocene, 1,2,3-selenadiazole, 1,2,3-thiadiazole. Introduction: Interest in the synthesis of selenium and sulfur containing compounds and the further utilization of these compounds in organic synthesis has been steadily increasing recently [1]. Particular interest in 1,2,3-selenadiazole and 1,2,3-thiadiazole derivatives stems from the fact that they can undergo a wide variety of reactions where they act as 1,3-dipoles or as a source of selenium or sulfur and hence they have attracted much attention for the synthesis of different organoselenium and organosulfur comp