new advances in titanium-mediated free radical reactionstitanium-mediated自由基反应的新进展.pdfVIP

Molecules 2012, 17, 14700-14732; doi:10.3390/molecules171214700 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review New Advances in Titanium-Mediated Free Radical Reactions Bianca Rossi 1, Simona Prosperini 1,2, Nadia Pastori 1, Angelo Clerici 1 and Carlo Punta 1,2,* 1 Department of Chemistry, Materials, and Chemical Engineering “Giulio Natta”, Politecnico di Milano, P.zza Leonardo da Vinci 32, 20133 Milano, Italy; E-Mails: brossi@chem.polimi.it (B.R.); sperini@chem.polimi.it (S.P.); nadia.pastori@polimi.it (N.P.); angelo.clerici@polimi.it (A.C.) 2 INSTM (National Consortium for Materials Science and Technology) Local Unit, Politecnico di Milano, 20133 Milan, Italy * Author to whom correspondence should be addressed; E-Mail: carlo.punta@polimi.it; Tel.: +39-022-399-3026; Fax: +39-022-399-3180. Received: 31 October 2012; in revised form: 28 November 2012 / Accepted: 6 December 2012 / Published: 11 December 2012 Abstract: Titanium complexes have been widely used as catalysts for C-C bond-forming processes via free-radical routes. Herein we provide an overview of some of the most significant contributions in the field, that covers the last decade, emphasizing the key role played by titanium salts in the promotion of selective reactions aimed at the synthesis of multifunctional organic compounds, including nucleophilic radical additions to imines, pinacol and coupling reactions, ring opening of epoxides and living polymerization. Keywords: radical chemistry; titanium;