原创力文档mycophenolic acid counteracts b cell proliferation and plasmablast formation in patients with systemic lupus erythematosus霉酚酸抵消b细胞增殖和plasmablast形成系统性红斑狼疮患者.pdfVIP
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mycophenolic acid counteracts b cell proliferation and plasmablast formation in patients with systemic lupus erythematosus霉酚酸抵消b细胞增殖和plasmablast形成系统性红斑狼疮患者
Eickenberg et al. Arthritis Research Therapy 2012, 14:R110
/content/14/3/R110
RESEARCH ARTICLE Open Access
Mycophenolic acid counteracts B cell proliferation
and plasmablast formation in patients with
systemic lupus erythematosus
1,2 1,2 1,2 3 2
Sebastian Eickenberg , Eva Mickholz , Elisabeth Jung , Jerzy-Roch Nofer , Herrmann Pavenstädt and
Annett M Jacobi1,2*
Abstract
Introduction: Clinical trials revealed a high efficacy of mycophenolate mofetil (MMF) in inducing and maintaining
remission in patients with class III-V-lupus nephritis. Also extrarenal manifestations respond to MMF treatment.
However, few attempts have been undertaken to delineate its mechanism of action in systemic lupus
erythematosus (SLE) a disease characterized by enhanced B cell activation.
Methods: Clinical and paraclinical parameters of 107 patients with SLE were recorded consecutively and analyzed
retrospectively. Patients were divided into treatment groups (MMF: n = 39, azathioprine (AZA) n = 30 and controls
without immunosuppressive therapy n = 38). To further delineate the effect of mycophenolic acid (MPA) on naive
and memory B cells in vitro assays were performed.
Results: Although patients taking AZA flared more frequently than patients on MMF or controls, the analysis of
clinical parameters did not reveal significant differences. However, profound differences in paraclinical parameters
were found. B cell frequencies and numbers were significantly higher in patients taking MMF compared to those
on AZA but lower numbers and frequencies of plasmablasts were detected compared to AZA-treated patients or
controls. Notably, MMF treatment was associated with a significantly higher frequency and number of t
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