原创力文档myocardial post-conditioning with danshen-gegen decoction protects against isoproterenol-induced myocardial injury via a pkcεmkatp-mediated pathway in rats心肌后置条件与danshen-gegen汤预防isoproterenol-induced通过pkcεmkatp-mediated通路在大鼠心肌损伤.pdfVIP
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myocardial post-conditioning with danshen-gegen decoction protects against isoproterenol-induced myocardial injury via a pkcεmkatp-mediated pathway in rats心肌后置条件与danshen-gegen汤预防isoproterenol-induced通过pkcεmkatp-mediated通路在大鼠心肌损伤
Wong et al. Chinese Medicine 2011, 6:7
/content/6/1/7
RESEARCH Open Access
Myocardial post-conditioning with Danshen-
Gegen decoction protects against isoproterenol-
induced myocardial injury via a PKCε/mKATP-
mediated pathway in rats
1 1 1 2 2 1 1*
Sze Man Wong , Po Yee Chiu , Hoi Yan Leung , Limin Zhou , Zhong Zuo , Philip Y Lam , Kam Ming Ko
Abstract
Background: Danshen-Gegen decoction (DG), a Chinese herbal formula, has been demonstrated to be effective for
the treatment of coronary heart disease such as myocardial infarction. In the present study, we investigated the
effect of DG post-conditioning on isoproterenol (ISO)-induced myocardial injury in rats.
Methods: ISO was injected intraperitoneally (200 mg/kg) to induce acute (2-6 hours) myocardial injury in adult
female rats. DG (4 g/kg) was administered per oral immediately after the injection of ISO in the rats. Extent of
myocardial injury was assessed by measurements of plasma enzyme activities. Myocardial mitochondrial
glutathione antioxidant status, lipid peroxidation and mitochondrial calcium ion loading and cytochrome c release
were also measured. Effects of inhibitors of protein kinase C-epsilon (PKCε) ranslocation and mitochondrial
ATP-sensitive potassium channel (mKATP) on myocardial post-conditioning by DG were investigated.
Results: ISO inflicted acute myocardial injury in the rats as evidenced by increased plasma enzyme activities. DG
post-treatment alleviated the ISO-induced acute myocardial injury.
Conclusion: DG post-treatment protected the myocardium against ISO-induced acute injury in rats. The myocardial
post-conditioning by DG is likely mediated by PKCε/mKATP signaling pathway.
Background
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