原创力文档neutrophil connectivity key to neutrophil-mediated tissue injury中性粒细胞的连通性neutrophil-mediated组织损伤的关键.pdfVIP
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neutrophil connectivity key to neutrophil-mediated tissue injury中性粒细胞的连通性neutrophil-mediated组织损伤的关键
Available online /content/7/4/285
Commentary
Neutrophil ‘connectivity’: key to neutrophil-mediated tissue injury?
Salahaddin Mahmudi-Azer1 and Stephan F van Eeden2
1Senior Post-Doctoral fellow, Department of Medicine, University of British Columbia, U.B.C. McDonald Research Laboratory iCAPTURE Centre,
St Pauls Hospital, Vancouver BC, Canada
2Associate Professor, Department of Medicine, University of British Columbia, U.B.C. McDonald Research Laboratory iCAPTURE Centre,
St Pauls Hospital, Vancouver BC, Canada
Correspondence: Stephan F van Eeden, svaneeden@mrl.ubc.ca
Published online: 24 February 2003 Critical Care 2003, 7:285-287 (DOI 10.1186/cc1884)
This article is online at /content/7/4/285
© 2003 BioMed Central Ltd (Print ISSN 1364-8535; Online ISSN 1466-609X)
Abstract
Neutrophils use cell surface molecules to communicate with their external environment. These
molecules are markers reflecting neutrophil development, activation status and cell function. They are
also critically important in controlling neutrophil behavior. Targeting these cell surface molecules is an
attractive approach in the treatment of neutrophil-mediated conditions.
Keywords connectivity, inflammation, neutrophils, surface molecules, tissue injury
Neutrophils are professional phagocytic cells that provide during every stage of the neutrophil’s lifespan. Cell surface
the host with a first line of defense against acute bacterial molecules alter with neutrophil proliferation, differentiation,
and fungal diseases. They sense the focus of infection, they maturation and the release of cells from the marrow into the
adhere to the endothelium of capillaries and venules
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