new chiral p-n ligands for the regio- and stereoselective pd-catalyzed dimerization of styrene新的手性pn配体区和立体选择pd-catalyzed苯乙烯二聚作用.pdfVIP

Molecules 2011, 16, 1804-1824; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article New Chiral P-N Ligands for the Regio- and Stereoselective Pd-Catalyzed Dimerization of Styrene 1 1 1 2 1 Lidia Fanfoni , Angelo Meduri , Ennio Zangrando , Sergio Castillon , Fulvia Felluga and Barbara Milani 1,* 1 Dipartimento di Scienze Chimiche e Farmaceutiche, Università di Trieste, Via Licio Giorgieri 1, 34127 Trieste, Italy; E-Mails: lfanfoni@units.it (L.F.); angelo.meduri@phd.units.it (A.M.); ezangrando@units.it (E.Z.); ffelluga@units.it (F.F.) 2 Department de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, C. Marcel.lí Domingo s/n 43007 Tarragona, Spain; E-Mail: sergio.castillon@ (S.C.) * Author to whom correspondence should be addressed; E-Mail: milaniba@units.it; Tel.: +39-040-558-3956; Fax: +39-040-558-3903. Received: 27 December 2010; in revised form: 17 February 2011 / Accepted: 18 February 2011 / Published: 22 February 2011 Abstract: Two new chiral, enantiomerically pure, hybrid P-N ligands, namely (2R,5S)-2- phenyl-3-(2-pyridyl)-1,3-diaza-2-phosphanicyclo[3,3,0]octan-4-one (1) and (2R,5S)-2- phenyl-3-(2-pyridyl)-1,3-diaza-2-phosphanicyclo[3,3,0]octane (2), have been synthesized starting from L-proline. The two ligands differ in the presence or not of a carbonyl group in the diazaphosphane ring. Their coordination chemistry towards Pd