new chiral phosphoramidite complexes of iron as catalytic precursors in the oxidation of activated methylene groups新的手性phosphoramidite复合物催化前体的铁的氧化活性亚甲基组.pdfVIP

Molecules 2010, 15, 2631-2650; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article New Chiral Phosphoramidite Complexes of Iron as Catalytic Precursors in the Oxidation of Activated Methylene Groups Pushkar Shejwalkar 1, Nigam P. Rath 2 and Eike B. Bauer 1,* 1 University of Missouri - St. Louis, Department of Chemistry and Biochemistry, One University Boulevard, St. Louis, MO 63121, USA; E-Mail: pssgk8@ (P.S.) 2 Department of Chemistry and Biochemistry and Center for Nanoscience, University of Missouri - St. Louis, One University Boulevard, St. Louis, MO 63121, USA; E-Mail: rathn@ (N.P.R.) * Author to whom correspondence should be addressed; E-Mail: bauere@; Tel.: +1-314-516- 5311; Fax: +1-314-516-5342. Received: 21 February 2010; in revised form: 31 March 2010 / Accepted: 6 April 2010 / Published: 12 April 2010 Abstract: New phosphoramidite complexes of iron were synthesized and structurally characterized. Reaction of the known chiral phosphoramidites (RO) PNR’ (R = 2 2 binaphthyl, R’ = CH , 1a; R = binaphthyl, R’ = benzyl, 1b) with [FeBr(Cp)(CO) ] afforded 3 2 the title compounds [FeBr(Cp)(CO)(1a,b)] (4a,b) in 34 and 65 % isolated yields as mixtures of diastereomers, since both the metal and the ligand are stereogenic. Simil