new cucurbitane triterpenoids and steroidal glycoside from momordica charantia新cucurbitane常用药用,从苦瓜甾体糖苷.pdfVIP

Molecules 2009, 14, 4804-4813; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article New Cucurbitane Triterpenoids and Steroidal Glycoside from Momordica charantia Jie-Qing Liu, Jian-Chao Chen, Cui-Fang Wang and Ming-Hua Qiu * State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204 Yunnan, China; E-Mails: jqliu18@163.com(J.Q.L.); jcchen@(J.C.C.); wlycf@163.com(C.F.W.) * Author to whom correspondence should be addressed; E-Mail: mhchiu@; Tel.: +86-871-5223257; Fax: +86-871-5223255. Received: 26 October 2009; in revised form: 9 November 2009 / Accepted: 11 November 2009 / Published: 25 November 2009 Abstract: Three new cucurbitane triterpenoids 1–3 and one new steroidal glycoside 4, were isolated together with ten known compounds from Momordica charantia . The structures of new compounds were determined to be 19(R)-n-butanoxy-5β,19- epoxycucurbita-6,23-diene-3β,25-diol 3-O-β-glucopyranoside (1), 23-O-β-allopyranosyle- cucurbita-5,24-dien-7α,3β,22(R),23(S)-tetraol 3-O-β-allopyranoside. (2), 23(R),24(S),25- trihydroxycucurbit-5-ene 3-O-{[β-glucopyranosyl(1→6)]-O-β-glucopyranosyl}-25-O-β- glucopyranoside (3), and 24(R)-stigmastan-3β,5α,6β-triol-25-ene 3-O-β-glucopyranoside (4), respectively. Their structures were elucidated by the combination of mass spectrometry (MS), one and two-dimensional N