new developments in osteoarthritis. sex differences in magnetic resonance imaging-based biomarkers and in those of joint metabolism骨关节炎的新发展。.pdfVIP

Maleki-Fischbach and Jordan Arthritis Research Therapy 2010, 12:212 /content/12/4/212 R E V I E W Sex dif erences in magnetic resonance imaging- based biomarkers and in those of joint metabolism Mehrnaz Maleki-Fischbach and Joanne M Jordan* Results of clinical and epidemiologic studies have been Abstract confl icting [5-7], with some showing a protective eff ect Sex dif erences in the prevalence, incidence, and for estrogen or hormone replacement therapy (HRT) on severity of osteoarthritis (OA) have long been known. radiographic knee and hip OA [8,9] or progression to Some dif erences in the evaluation of this issue across joint replacement [10] but no eff ect on joint symptoms studies may be related to dif erences in study design, [11]. Diff erences in study results can be ascribed to sampling, study size, study populations, targeted joint diff erences in (a) study populations and study designs; (b) sites, and dei nitions of OA. This report highlights distribution of, or confounding by, other risk factors such recent studies of sex dif erences in individual joint as age, race/ethnicity, body mass index (BMI), and smok- components imaged by magnetic resonance imaging ing; and (c) joints aff ected by OA and defi nitions used to and in systemic biomarkers of joint metabolism. defi ne OA [3] and statistical method ology. A recent sys- Particularly important are those studies that examine tem atic review of 17 studies illustrates this point. h ere this issue in young unaf ected adults and childre