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nano-bio-technology and sensing chips new systems for detection in personalized therapies and cell biologynano-bio-technology和传感芯片新系统在个性化治疗和细胞生物学检测
Sensors 2010, 10, 526-543; doi:10.3390/s100100526
OPEN ACCESS
sensors
ISSN 1424-8220
/journal/sensors
Review
Nano-Bio-Technology and Sensing Chips: New Systems for
Detection in Personalized Therapies and Cell Biology
Sandro Carrara
Swiss Federal Institute of Technology-Lausanne, (EPFL)-EPFL IC ISIM LSI1-INF 338 (Bâtiment
INF), Station 14 CH-1015 Lausanne, Switzerland; E-Mail: sandro.carrara@epfl.ch;
Tel.: +41-21-693-0915; Fax: +41-21-693-0909
Received: 24 November 2009; in revised form: 30 December 2009 / Accepted: 5 January 2010 /
Published: 12 January 2010
Abstract: Further advances in molecular medicine and cell biology also require new
electrochemical systems to detect disease biomarkers and therapeutic compounds.
Microelectronic technology offers powerful circuits and systems to develop innovative and
miniaturized biochips for sensing at the molecular level. However, microelectronic biochips
proposed in the literature often do not show the right specificity, sensitivity, and reliability
required by biomedical applications. Nanotechnology offers new materials and solutions to
improve the surface properties of sensing probes. The aim of the present paper is to review
the most recent progress in Nano-Bio-Technology in the area of the development
of new electrochemical systems for molecular detection in personalized therapy and cell
culture monitoring.
Keywords: biochip; DNA; enzymes; cytochromes; antibodies; carbo
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