new genetic links in eosinophilic esophagitis嗜酸性食管炎的新基因的链接.pdfVIP

Spergel Genome Medicine 2010, 2:60 /content/2/9/60 CO M M E N TA R Y New genetic links in eosinophilic esophagitis Jonathan M Spergel* EoE varies with age: infants and toddlers often have Abstract difficulty feeding and fail to thrive, school-age children Eosinophilic esophagitis (EoE) is increasingly diagnosed present with vomiting and epigastric or chest pain, and as a disorder throughout the world. It is characterized adolescents and adults present with dysphagia and food by eosinophils in the esophagus due to food allergies. impaction [3]. Molecular analysis of esophageal biopsies and mouse EoE is considered a food-allergy-related disorder on models have indicated a clear role for the T helper 2 the basis of several findings. Most patients are atopic pathway, in particular interleukins 5 and 13, in this individuals (that is, they have a high rate of food allergen disease. Current treatment options for EoE involve sensitization as determined using skin prick and patch avoidance of the allergens or using anti-inammatory testing); in addition, EoE patients have a higher rate of medications such as topical corticosteroids. In the past food anaphylaxis than the general population [4]. More- year, genomic research has led to the identication over, nearly all EoE patients have complete remission of single nucleotide polymorphisms in the gene following introduction of an elemental formula diet that encoding thymic stromal lymphopoietin (