na+,k+-atpase as the target enzyme for organic and inorganic compoundsna +,k + atp酶作为目标酶为有机和无机化合物.pdfVIP

Sensors 2008, 8, 8321-8360; DOI: 10.3390/s8128321 OPEN ACCESS sensors ISSN 1424-8220 /journal/sensors Review + + Na ,K -ATPase as the Target Enzyme for Organic and Inorganic Compounds 1, 1 1 2 Vesna Vasić *, Tatjana Momić , Marijana Petković and Danijela Krstić 1 Vinča Institute of Nuclear Sciences, Department of Physical Chemistry, 11001 Belgrade, Republic of Serbia; E-Mails: momict@vinca.rs. (T. M.); marijanapetkovic@vinca.rs (M. P.) 2 Institute of Medicinal Chemistry, University School of Medicine, University of Belgrade, Višegradska 12, Belgrade, Republic of Serbia; E-Mail: krsticdana@ (D. K.) * Author to whom correspondence should be addressed; E-Mail: evasic@vinca.rs (V. V.); Tel.: +381 11 340 8287; Fax: +381 11 244 7207 (evasic@vinca.rs) Received: 3 November 2008; in revised form: 9 December 2008 / Accepted: 11 December 2008 / Published: 15 December 2008 Abstract: This paper gives an overview of the literature data concerning specific and non + + specific inhibitors of Na ,K -ATPase receptor. The immobilization approaches developed to improve the rather low time and temperature stability of Na+ + ,K -ATPase, as well to preserve the enzyme properties were overviewed. The functional immobilization of + + Na ,K -ATPase receptor as the target, with