new di-(β-chloroethyl)-α-amides on n-(meta-acylaminobenzoyl)- d,l-aminoacid supports with antitumoral activity(新di)-β-chloroethyl -α-amides n -(meta-acylaminobenzoyl)d,l-aminoacid支持antitumoral活动.pdfVIP
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new di-(β-chloroethyl)-α-amides on n-(meta-acylaminobenzoyl)- d,l-aminoacid supports with antitumoral activity(新di)-β-chloroethyl -α-amides n -(meta-acylaminobenzoyl)d,l-aminoacid支持antitumoral活动
Molecules 2008, 13, 177-189
molecules
ISSN 1420-3049
© 2007 by MDPI
/molecules
Full Research Paper
New Di-(β-chloroethyl)-α-amides on N-(meta-Acylamino-
benzoyl)-D,L-aminoacid Supports with Antitumoral Activity
Valeriu Sunel 1, Marcel Popa 2, Jacques Desbrières 3, Lenuta Profire 4,*, Pintilie Otilia 1 and
Lionte Catalina 5
1 Department of Organic Chemistry and Biochemistry, Faculty of Chemistry, Al. I. Cuza University,
Iasi, 11 B-dul Carol I, 700506, Romania; e-mails: vsunel@uaic.ro (for Sunel),
povpintilie@ (for Otilia)
2 Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental
Protection, Gh. Asachi Technical University, 71A B-dul Mangeron, Iasi, 700050, Romania; e-mail:
marpopa@ch.tuiasi.ro
3 Institut Pluridisciplinaire de Recherche sur l’Environnement et les Matériaux – Equipe de Physique
et Chimie des Polymèrs (IPREM/EPCP), UMR 5254 CNRS – Pau et Pays de l’Adour University,
Hélioparc Pau Pyrénées 2, av. President Angout, 64053 Pau Cedex 09, France
4 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gr. T. Popa Medicine and Pharmacy
University, 16 Universitatii Street, 700115, Romania
5 Medical Clinic, Emergency Clinic Hospital, Faculty of Medicine, Gr. T. Popa Medicine and
Pharmacy University, 16 Universitatii Street, 700115, Romania
* Author to whom correspondence should be addressed; E-mail: nprofire@; Phone:
(+40)232 267801; Fax: (+40) 232 211802.
Received: 30 December 2007; in revised form: 23 January 2008 / Accepted: 23 January 2008 /
Published: 28 January 2008
Abstract: In order to obtain new compounds
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