原创力文档new biocompatible polyesters derived from α-amino acids hydrolytic degradation behavior新型生物相容性聚酯源自α-amino酸水解降解行为.pdfVIP
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new biocompatible polyesters derived from α-amino acids hydrolytic degradation behavior新型生物相容性聚酯源自α-amino酸水解降解行为
Polymers 2010, 2, 418-439; doi:10.3390/polym2040418
OPEN ACCESS
polymers
ISSN 2073-4360
/journal/polymers
Article
New Biocompatible Polyesters Derived from α-Amino Acids:
Hydrolytic Degradation Behavior
Naomi Cohen-Arazi *, Abraham J. Domb and Jeoshua Katzhendler
Institute of Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of
Jerusalem, Israel; E-Mails: avid@ekmd.huji.ac.il (A.J.D.); katzhe@cc.huji.ac.il (J.K.)
* Author to whom correspondence should be addressed; E-Mail: naomic@ekmd.huji.ac.il;
Tel.: 972-2-6758691; Fax: 972-2-6757076.
Received: 20 September 2010; in revised form: 2 October 2010 / Accepted: 8 October 2010 /
Published: 13 October 2010
Abstract: New polymers were synthesized from α-hydroxy acids derived from the natural
amino acids Ile, Leu, Phe, and Val, combined with lactic acid, glycolic acid
and 6-hydroxyhexanoic acid by direct condensation. The toxicity was determined and the
degradation process of these polyesters was investigated under physiological conditions by
analyzing the composition of the degraded polymers and the oligomers cleaved in the
buffer medium. The polymers were found to be non toxic to two cell lines. Polymers
displayed a biphasic degradation behavior. In most cases, a linear relationship was found
between the weight loss constant and the hydrophobicity of the polymers, Log P.
Regarding the second stage of weight loss, it is apparent that polymers
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