new anti-inflammatory and anti-proliferative constituents from fermented red mold rice monascus purpureus ntu 568新的抗炎和anti-proliferative成分从发酵红模具水稻红紫色南大568.pdfVIP

Molecules 2010, 15, 7815-7824; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article New Anti-Inflammatory and Anti-Proliferative Constituents from Fermented Red Mold Rice Monascus purpureus NTU 568 Ya-Wen Hsu 1,2, Li-Chuan Hsu 1,2, Chao-Lin Chang 2, Yu-Han Liang 1,2, Yao-Haur Kuo 2,3,* and Tzu-Ming Pan 1,* 1 Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan 10617, Taiwan 2 Division of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei, Taiwan 11221, Taiwan 3 Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan 40402, Taiwan * Authors to whom correspondence should be addressed; E-Mails: kuoyh@.tw (Y.-H.K.); tmpan@.tw (T.-M.P.); Tel.: +886-2-2820-1999 ext. 7061 (Y.-H.K.); +886-2-3366-4519 ext. 10 (T.-M.P.); Fax: +886-2-2823-6150 (Y.-H.K.); +886-2-3366-3838 (T.-M.P.). Received: 14 October 2010; in revised form: 29 October 2010 / Accepted: 1 November 2010 / Published: 3 November 2010 Abstract: Six azaphilonoid derivatives, including two new blue fluorescent monapurfluores A (1) and B (2), two known pyridine-containing molecules, monascopyridines C (3) and D (4), and two known monasfluores A (5) and B (6), were isolated and characterized from red mold rice fermented by Monascus purpureus NTU 1 568. Structural elucidation o