new acetylenic norlignan compounds from rhizomes of curculigo crassifolia新炔属norlignan化合物从根状茎curculigo植.pdfVIP

Molecules 2008, 13, 1696-1701; DOI: 10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /molecules Article New Acetylenic Norlignan Compounds from Rhizomes of Curculigo crassifolia Kai-jin Wang 1, Ning Li 1,* and Hu Wang 2 1 College of Life Sciences, Anhui University, Hefei 230039, P. R. China; E-mail: wkjahla@ (Kai-jin Wang) 2 Modern Experiment Technology Center, Anhui University, Hefei 230039, P. R. China; E-mail: wanghu@ (Hu Wang) * Author to whom correspondence should be addressed. E-mail: ln0110@; Tel.: +86-551-5107341; Fax: +86-551-5107354. Received: 13 June 2008; in revised form: 1 August 2008 / Accepted: 6 August 2008 / Published: 13 August 2008 Abstract: Two pairs of diastereoisomeric acetylenic norlignan compounds with PhCH(OR )CH(OR )CH C≡CPh skeleta: (1R, 2R)-1-O-methylnyasicoside (1) and (1S, 1 2 2 2R)-1-O-methylnyasicoside (2), and (1R, 2R)-crassifogenin D (3) and (1S, 2R)- crassifogenin D (4), were isolated from the ethanolic extract of rhizomes of Curculigo crassifolia. Compounds 3 and 4 are new and their structures were elucidated on the basis of spectroscopic evidence and comparisons with literature data. Keywords: Curculigo crassifolia; Hypoxidaceae; acetylenic norlignan compounds Introduction Curculigo crassifolia (Bak.) Hook. f. belongs to the Hypoxidaceae family and is found throughout the Western and Southern regions of China. Its rhizomes are used as a tonic a