原创力文档myeloid dendritic cells display downregulation of c-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus髓系树突状细胞的c型凝集素受体和差别显示对这些异常的系统性红斑狼疮中凝集素的吸收.pdfVIP
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myeloid dendritic cells display downregulation of c-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus髓系树突状细胞的c型凝集素受体和差别显示对这些异常的系统性红斑狼疮中凝集素的吸收
Available online /content/10/5/R114
Vol 10 No 5 Open Access
Research article
Myeloid dendritic cells display downregulation of C-type lectin
receptors and aberrant lectin uptake in systemic lupus
erythematosus
Seetha U Monrad, Kristine Rea, Seth Thacker and Mariana J Kaplan
Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, 1150 West Medical Center Drive, 5520 MSRBI,
Ann Arbor, MI 48109, USA
Corresponding author: Mariana J Kaplan, makaplan@
Received: 6 Aug 2008 Revisions requested: 16 Sep 2008 Revisions received: 18 Sep 2008 Accepted: 23 Sep 2008 Published: 23 Sep 2008
Arthritis Research Therapy 2008, 10:R114 (doi:10.1186/ar2517)
This article is online at: /content/10/5/R114
© 2008 Monrad et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction There is a growing body of evidence implicating Results When compared with dendritic cells from healthy
aberrant dendritic cell function as a crucial component in the control individuals, unstimulated and stimulated lupus dendritic
immunopathogenesis of systemic lupus erythematosus. The cells displayed significantly decreased dextran uptake and
purpose of the present study was to characterize the phagocytic mannose receptor and dendritic cell-specific intercellular
capacity and expression of receptors involved in pathogen adhesion molecule-grabbing nonintegrin expression. Decreased
recognition and self-nonself discrimination on myeloid de
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