new 2-arylbenzofurans from the root bark of artocarpus lakoocha新2-arylbenzofurans树皮从根面包果lakoocha.pdfVIP

Molecules 2010, 15, 6548-6558; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article New 2-Arylbenzofurans from the Root Bark of Artocarpus lakoocha Boonchoo Sritularak 1, Kullasap Tantrakarnsakul 1, Kittisak Likhitwitayawuid 1,* and 2 Vimolmas Lipipun 1 Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand 2 Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand * Author to whom correspondence should be addressed; E-Mail: Kittisak.L@chula.ac.th; Tel.: +66-221-88-360; Fax: +66-221-88-357. Received: 29 June 2010; in revised form: 15 September 2010 / Accepted: 17 September 2010 / Published: 17 September 2010 Abstract: Three new prenylated 2-arylbenzofurans – artolakoochol, 4-hydroxy- artolakoochol and cycloartolakoochol – have been isolated from the root bark of Artocarpus lakoocha Roxb., Their structures were elucidated through analysis of their spectroscopic data, and their antiherpetic potential was evaluated by the plaque reduction assay. Keywords: Artocarpus lakoocha ; Moraceae; 2-arylbenzofuran; anti-herpetic activity 1. Introduction Artocarpus lakoocha Roxb. (Moraceae), locally known in Thai as “Ma-Haad”, is a widely distributed tree in the regions of South and S