neutrophils and interferon-α-producing cells who produces interferon in lupus中性粒细胞和interferon-α-producing细胞产生干扰素在红斑狼疮.pdfVIP

Decker Arthritis Research Therapy 2011, 13:118 /content/13/4/118 COMMENTARY Neutrophils and interferon-α-producing cells: who produces interferon in lupus? Patrice Decker* receptor (TLR) 9 and TLR7, respectively, in cooperation Abstract with CD32 [6-8]. Nevertheless, PDC deple tion experi- Interferon-α plays a crucial role in the pathogenesis ments suggest that other cell types produce IFN-α in SLE of systemic lupus erythematosus. Nevertheless, the [2] and type I IFN production occurs independently of dif erent human cell types producing this cytokine as Fcγ receptors in a lupus mouse model [9], indicating that well as the stimuli inducing its production have not uptake of immune complexes is not required. In a been completely characterized. So far, a subpopulation diff erent lupus mouse model, the double-stranded RNA of dendritic cells activated by immune complexes has analog poly I:C was shown to induce IFN-α production in been identii ed as major producers of interferon-α in spleen monocytes [10], confi rming that – depending on patients with lupus. However, those cells represent the stimulus – cells other than PDCs may produce IFN-α a minor population and some studies have reported independently of the presence of immune complexes. the secretion of interferon-α by other cells. On the Interestingly, Fairhurst and colleagues [11] recently other hand, more than 50% of blood leukocytes showed that type I IFNs are produced by resident renal are neutrophils and their functions are still not fully cells, sugges