new “green” approaches to the synthesis of pyrazole derivatives新的u201c绿色u201d吡唑衍生物的合成方法.pdfVIP

Molecules 2007, 12, 1482-1495 molecules ISSN 1420-3049 © 2007 by MDPI /molecules Full Paper New “Green” Approaches to the Synthesis of Pyrazole Derivatives Anna Corradi 1, Cristina Leonelli 1, Antonino Rizzuti 1, Roberto Rosa 1,*, Paolo Veronesi 1, 2 3 3 Romano Grandi , Sara Baldassari and Carla Villa 1 Dipartimento di Ingegneria dei Materiali e dell’Ambiente, Università degli Studi di Modena e Reggio Emilia, Via Vignolese, 905, 41100 Modena, Italy. FAX: +390592056243; tel: +390592056247; e-mails: corradi.anna@unimore.it, leonelli@unimore.it, rizzuti.antonino@unimore.it, paolov@unimore.it 2 Dipartimento di Chimica, Università degli Studi di Modena e Reggio Emilia, Via Campi, 183, 41100 Modena, Italy; e-mail: romano@unimore.it 3 Dipartimento di Scienze Farmaceutiche dell’Università degli Studi di Genova, Viale Benedetto XV, 3, 16132 Genova, Italy; e-mails: s.baldassari@unige.it, carlavilla@unige.it * Author to whom correspondence should be addressed; e-mail: rosa.roberto@unimore.it Received: 31 May 2007; in revised form: 16 July 2007 / Accepted: 16 July 2007 / Published: 19 July 2007 Abstract: A novel approach to the synthesis of pyrazole derivatives from tosylhydrazones of α,β-unsaturated carbonyl compounds possessing a β-hydrogen is proposed, exploiting microwave (MW) activation coupled with solvent free reaction conditions. The cycloaddition was studied on three ketones (trans-4-phenyl-3-buten-2-one, β-ionone