原创力文档neuroprotective effects of herbal ethanol extracts from gynostemma pentaphyllum in the 6-hydroxydopamine-lesioned rat model of parkinsons disease神经保护作用的中药乙醇提取物绞股蓝在6-hydroxydopamine-lesioned帕金森病大鼠模型.pdfVIP
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neuroprotective effects of herbal ethanol extracts from gynostemma pentaphyllum in the 6-hydroxydopamine-lesioned rat model of parkinsons disease神经保护作用的中药乙醇提取物绞股蓝在6-hydroxydopamine-lesioned帕金森病大鼠模型
Molecules 2010, 15, 2814-2824; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
Neuroprotective Effects of Herbal Ethanol Extracts from
Gynostemma pentaphyllum in the 6-Hydroxydopamine-Lesioned
Rat Model of Parkinsons Disease
1 1 2 1 1
Hyun Sook Choi , Mi Sook Park , Seung Hwan Kim , Bang Yeon Hwang , Chong Kil Lee
and Myung Koo Lee 1,*
1 College of Pharmacy and Research Center for Bioresource and Health, Chungbuk National
University, Cheongju 361-763, Korea; E-Mails: 6151494@ (H.S.C);
parkms@cnuh.co.kr (M.S.P); byhwang@chngbuk.ac.kr (B.Y.H); cklee@chungbuk.ac.kr (C.K.L)
2 College of Physical Education, Kyunghee University, Youngin 449–701, Korea;
E-Mail: barkleyk34@khu.ac.kr (S.H.K)
* Author to whom correspondence should be addressed; E-Mail: myklee@chungbuk.ac.kr;
Tel: +82-43-261-2822; Fax: +82-43-276-2754.
Received: 20 February 2010; in revised form: 25 March 2010 / Accepted: 1 April 2010 /
Published: 16 April 2010
Abstract: 6-Hydroxydopamine administration for 28 days (8 μg/2 μL) reduced the number
of tyrosine hydroxylase (TH)-immunopositive neurons to 40.2% in the substantia nigra
compared to the intact contralateral side. Dopamine, 3,4-dihydroxyphenylacetic acid,
homovanillic acid and norepinephrine levels were reduced to 19.1%, 52.3%, 47.1% and
67.4% in the striatum of 6-hydroxydopamine-lesioned rats compared to t
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