原创力文档myeloid dendritic cells correlate with clinical response whereas plasmacytoid dendritic cells impact autoantibody development in rheumatoid arthritis patients treated with infliximab髓系树突状细胞与临床反应而血浆树突细胞影响自身抗体发展与英夫利昔单抗治疗类风湿性关节炎患者.pdfVIP
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myeloid dendritic cells correlate with clinical response whereas plasmacytoid dendritic cells impact autoantibody development in rheumatoid arthritis patients treated with infliximab髓系树突状细胞与临床反应而血浆树突细胞影响自身抗体发展与英夫利昔单抗治疗类风湿性关节炎患者
Available online /content/11/3/R100
Vol 11 No 3 Open Access
Research article
Myeloid dendritic cells correlate with clinical response whereas
plasmacytoid dendritic cells impact autoantibody development in
rheumatoid arthritis patients treated with infliximab
1,2 1 1 1
Christophe Richez , Thierry Schaeverbeke , Chantal Dumoulin , Joël Dehais , Jean-
François Moreau2,3 and Patrick Blanco2,3,4
1Département de Rhumatologie, CHU Bordeaux, place Amélie Raba-Léon, 33076 Bordeaux, France
2UMR-CNRS 5164, Université Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux, France
3Département de Virologie et dImmunologie biologique, CHU Bordeaux, place Amélie Raba-Léon, 33076 Bordeaux, France
4Service de Médecine Interne, CHU Bordeaux, 1 Avenue de Magellan, 33600 Pessac, France
Corresponding author: Christophe Richez, christophe.richez@ Patrick Blanco, patrick.blanco@chu-bordeaux.fr
Received: 15 Oct 2008 Revisions requested: 19 Dec 2008 Revisions received: 11 May 2009 Accepted: 29 Jun 2009 Published: 29 Jun 2009
Arthritis Research Therapy 2009, 11:R100 (doi:10.1186/ar2746)
This article is online at: /content/11/3/R100
© 2009 Richez et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction The objective of our study was to identify the Results RA patients with active disease were characterized by
significance of the subtypes of dendritic cell (DC), specifica
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