原创力文档non-medical use of opioids among hiv-infected opioid dependent individuals on opioid maintenance treatment the need for a more comprehensive approach非医疗使用阿片类药物的艾滋病毒感染个体阿片类依赖阿片类药物维持治疗需要一个更全面的方法.pdfVIP
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non-medical use of opioids among hiv-infected opioid dependent individuals on opioid maintenance treatment the need for a more comprehensive approach非医疗使用阿片类药物的艾滋病毒感染个体阿片类依赖阿片类药物维持治疗需要一个更全面的方法
Roux et al. Harm Reduction Journal 2011, 8:31
/content/8/1/31
RESEARCH Open Access
Non-medical use of opioids among HIV-infected
opioid dependent individuals on opioid
maintenance treatment: the need for a more
comprehensive approach
1,2,3* 1,2,3 1,2,3 4 1,2,3 5
Perrine Roux , Patrizia M Carrieri , Julien Cohen , Isabelle Ravaux , Bruno Spire , Michael Gossop and
Sandra D Comer6
Abstract
Background: Opioid maintenance treatment (OMT) has a positive impact on substance use and health outcomes
among HIV-infected opioid dependent patients. The present study investigates non-medical use of opioids by HIV-
infected opioid-dependent individuals treated with buprenorphine or methadone.
Methods: The MANIF 2000 study is a longitudinal study that enrolled a cohort of 476 HIV-infected opioid-dependent
individuals. Data were collected in outpatient hospital services delivering HIV care in France. The sample comprised
all patients receiving OMT (either methadone or buprenorphine) who attended at least one follow-up visit with data
on adherence to OMT (N = 235 patients, 1056 visits). Non-medical use of opioids during OMT was defined as having
reported use of opioids in a non-medical context, and/or the misuse of the prescribed oral OMT by an inappropriate
route of administration (injection or sniffing). After adjusting for the non-random assignment of OMT type, a model
based on GEE was then used to identify predictors of non-medical use of opioids.
Results: Among the 235 patients, 144 (61.3%) and 91 (38.9%) patients were receiving buprenorphine and
methadone, respectively, at baseline. Non-medical use of opioids was found in 41.6% of visits for 83% of individual
patients. In the multivariate an
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