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nonsteroidal anti-inflammatory drugs (nsaids) progress in small molecule drug development非甾体类抗炎药(非甾体抗炎药)小分子药物开发的进展
Pharmaceuticals 2010, 3, 1530-1549; doi:10.3390/ph3051530
OPEN ACCESS
pharmaceuticals
ISSN 1424-8247
/journal/pharmaceuticals
Review
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Progress in
Small Molecule Drug Development
Praveen P. N. Rao *, Saad N. Kabir and Tarek Mohamed
School of Pharmacy, Health Sciences Campus, University of Waterloo, 200 University Avenue W.
Waterloo, ON, N2L 3G1 Canada
* Author to whom correspondence should be addressed; Email: praopera@uwaterloo.ca;
Tel.: +1-519-888-4567, ext: 21317; Fax: +1-519-888-7910
Received: 01 April 2010; in revised form: 22 April 2010 / Accepted: 12 May 2010 /
Published: 14 May 2010
Abstract: Ever since the discovery of aspirin, small molecule therapeutics have been
widely prescribed to treat inflammation and pain. Aspirin and several small molecule
NSAIDs are known to inhibit the enzymes cyclooxygenase-1 (COX-1) and -2 (COX-2).
Despite the success of NSAIDs to treat inflammatory disorders, the development of a
clinically useful small molecule NSAIDs with decreased side effect profiles is an ongoing
effort. The recent discovery and development of selective COX-2 inhibitors was a step
toward this direction. Emerging trends are represented by the progress in the development
of hybrid agents such as nitric oxide donor-NSAIDs (NO-NSAIDs) and dual
COX/lipoxygenase (LOX) inhibitors. This review focuses on the recent advances in the
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