non-steroidal anti-inflammatory drugs, variation in inflammatory genes, and aggressive prostate cancer非甾体类消炎药,炎症基因的变化,和侵略性前列腺癌.pdfVIP

Pharmaceuticals 2010, 3, 3127-3142; doi:10.3390/ph3103127 OPEN ACCESS pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Article Non-Steroidal Anti-Inflammatory Drugs, Variation in Inflammatory Genes, and Aggressive Prostate Cancer 1 2 3 4 1,2, Adam C. Reese , Jill Hardin , Iona Cheng , Graham Casey and John S. Witte * 1 Department of Urology, University of California at San Francisco, 1450 3rd Street, San Francisco, CA 94158, USA; E-Mail: areese@ (A.C.R.) 2 Epidemiology and Biostatistics and Institute for Human Genetics, University of California at San Francisco, 1450 3rd Street, San Francisco, CA 94158, USA; E-Mail: hardinj@ (J.H.) 3 Epidemiology Program, Cancer Research Center of Hawai`i, University of Hawai`i, Honolulu, HI 96813, USA 4 Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA * Author to whom correspondence should be addressed; E-Mail: wittej@; Tel.: +1-415-502-6882; Fax: +1-415-476-1356. Received: 9 August 2010; in revised form: 27 September 2010 / Accepted: 28 September 2010 / Published: 8 October 2010 Abstract: Increasing evidence suggests that prostatic inflammation plays a key role in the development of prostate cancer. It remains controversial whether non-steroidal anti- inflammatory drugs (NSAIDs) reduce the risk of prostate cancer. Here, we investigate how a previously reported inverse association between NSAID use and the risk of aggressive pro