non-steroidal anti-inflammatory drugs in alzheimers disease and parkinsons disease reconsidering the role of neuroinflammation非甾体抗炎药在阿尔茨海默病和帕金森病重新考虑神经炎症的作用.pdfVIP

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non-steroidal anti-inflammatory drugs in alzheimers disease and parkinsons disease reconsidering the role of neuroinflammation非甾体抗炎药在阿尔茨海默病和帕金森病重新考虑神经炎症的作用.pdf

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non-steroidal anti-inflammatory drugs in alzheimers disease and parkinsons disease reconsidering the role of neuroinflammation非甾体抗炎药在阿尔茨海默病和帕金森病重新考虑神经炎症的作用

Pharmaceuticals 2010, 3, 1812-1841; doi:10.3390/ph3061812 OPEN ACCESS pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Review Non-Steroidal Anti-Inflammatory Drugs in Alzheimers Disease and Parkinsons Disease: Reconsidering the Role of Neuroinflammation Amy H. Moore *, Matthew J. Bigbee, Grace E. Boynton, Colin M. Wakeham, Hilary M. Rosenheim, Christopher J. Staral, James L. Morrissey and Amanda K. Hund Department of Biology, Carleton College, one north college street, Northfield, MN 55057, USA * Author to whom correspondence should be addressed; E-Mail: amoore@; Tel.: +1-507-222-5981; Fax: +1-507-222-5757. Received: 8 April 2010; in revisedform: 10 May 2010 / Accepted: 2 June 2010 / Published: 2 June 2010 Abstract: Alzheimers disease (AD) and Parkinsons disease (PD) are the most common neurodegenerative diseases with age as the greatest risk factor. As the general population experiences extended life span, preparation for the prevention and treatment of these and other age-associated neurological diseases are warranted. Since epidemiological studies suggested that non-steroidal anti-inflammatory drug (NSAID) use decreased risk for AD and PD, increasing attention has been devoted to understanding the costs and benefits of the innate neuroinflammatory response to functional recovery following pathology onset. This review will provide a general overview on the role of neuroinflammation in these neurodegenerative diseases and an update on NSAID treatment in recent experimental