原创力文档obesity affects the chondrocyte responsiveness to leptin in patients with osteoarthritis肥胖影响软骨细胞的响应在骨关节炎患者瘦素.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
obesity affects the chondrocyte responsiveness to leptin in patients with osteoarthritis肥胖影响软骨细胞的响应在骨关节炎患者瘦素
Pallu et al. Arthritis Research Therapy 2010, 12:R112
/content/12/3/R112
R E S E A R C H A R T I C L E Open Access
Research article
Obesity affects the chondrocyte responsiveness to
leptin in patients with osteoarthritis
†1 †2 2 2 2 2
Stéphane Pallu , Pierre-Jean Francin , Cécile Guillaume , Pascale Gegout-Pottie , Patrick Netter , Didier Mainard ,
2 2
Bernard Terlain and Nathalie Presle*
Abstract
Introduction: Increasing evidence support the regulatory role of leptin in osteoarthritis (OA). As high circulating
concentrations of leptin disrupt the physiological function of the adipokine in obese individuals, the current study has
been undertaken to determine whether the elevated levels of leptin found in the joint from obese OA patients also
induce changes in the chondrocyte response to leptin.
Methods: Chondrocytes isolated from OA patients with various body mass index (BMI) were treated with 20, 100 or
500 ng/ml of leptin. The expression of cartilage-specific components (aggrecan, type 2 collagen), as well as regulatory
(IGF-1, TGFβ, MMP-13, TIMP 2) or inflammatory (COX-2, iNOS, IL-1) factors was investigated by real-time PCR to evaluate
chondrocyte responsiveness to leptin. Furthermore, the effect of body mass index (BMI) on leptin signalling pathways
was analyzed with an enzyme-linked immunosorbent assay for STATs activation.
Results: Leptin at 20 ng/ml was unable to modulate gene expression in chondrocytes, except for MMP-13 in obese OA
patients. Higher leptin levels induced the expression of IGF-1, type 2 collagen, TIMP-2 and MMP-13. However, the
activity of the adipokine was shown to be critically dependent on both the conce
您可能关注的文档
- nonlinear observer output-feedback mpc treatment scheduling for hiv非线性观测器输出反馈mpc调度艾滋病毒治疗.pdf
- non-linearity analysis of depth and angular indexes for optimal stereo slam非线性分析的深度和角度指标最佳音响大满贯.pdf
- non-linearity in wide dynamic range cmos image sensors utilizing a partial charge transfer technique非线性的宽动态范围cmos图像传感器利用部分电荷转移技术.pdf
- nonlinear magnetoelectric response of planar ferromagnetic-piezoelectric structures to sub-millisecond magnetic pulses平面ferromagnetic-piezoelectric结构的非线性磁电响应毫秒级的磁脉冲.pdf
- non-parametric methods for soil moisture retrieval from satellite remote sensing data非参数方法进行土壤水分从卫星遥感数据检索.pdf
- non-medical use of opioids among hiv-infected opioid dependent individuals on opioid maintenance treatment the need for a more comprehensive approach非医疗使用阿片类药物的艾滋病毒感染个体阿片类依赖阿片类药物维持治疗需要一个更全面的方法.pdf
- non-occupational exposure to paint fumes during pregnancy and risk of congenital anomalies a cohort study非职业化在怀孕期间接触油漆味和队列研究先天性畸形的风险.pdf
- non-pharmaceutical prevention of hip fractures – a cost-effectiveness analysis of a community-based elderly safety promotion program in sweden非药物预防髋部骨折u2014u2014社区老年人安全促进项目的成本效益分析在瑞典.pdf
- non-random mating for selection with restricted rates of inbreeding and overlapping generations的非随机交配选择限制的近亲繁殖率和世代交叠.pdf
- non-retroviral fossils in vertebrate genomes在脊椎动物基因组non-retroviral化石.pdf
- obesity and metabolic syndrome in 7-9 years-old portuguese schoolchildren肥胖和代谢综合征在7 - 9岁的葡萄牙学生.pdf
- obesity prevalence in a cohort of women in early pregnancy from a neighbourhood perspective肥胖患病率在一群妇女在怀孕的早期从社区的角度来看.pdf
- obesity prevalence estimates in a canadian regional population of preschool children using variant growth references肥胖患病率估计在加拿大地区学龄前儿童人口增长引用使用变体.pdf
- obesity drug update the lost decade减肥药更新u201c失去的十年u201d.pdf
- object-based classification of ikonos imagery for mapping large-scale vegetation communities in urban areas基于对象分类的ikonos图像映射大规模植被社区在城市地区.pdf
- obesity-associated insulin resistance is correlated to adipose tissue vascular endothelial growth factors and metalloproteinase levels肥胖相关胰岛素抵抗相关的脂肪组织血管内皮生长因子和金属蛋白酶的水平.pdf
- obesity and nutrition behaviours in western and palestinian outpatients with severe mental illness肥胖和营养行为在西方和巴勒斯坦门诊病人患有严重的精神疾病.pdf
- object-based classification of urban areas using vhr imagery and height points ancillary data基于对象的分类使用vhr城市意象和高度点辅助数据.pdf
- object-based land cover classification and change analysis in the baltimore metropolitan area using multitemporal high resolution remote sensing data基于对象的土地覆盖分类和变化分析在巴尔的摩市区使用多瞬时高分辨率遥感数据.pdf
- objective error criterion for evaluation of mapping accuracy based on sensor time-of-flight measurements客观的映射精度误差准则进行评估基于传感器飞行时间测量.pdf
文档评论（0）