oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo体内氧化磷脂减少ventilator-induced血管渗漏和炎症.pdfVIP

Available online /content/12/1/R27 Vol 12 No 1 Open Access Research Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo 1 2 2 2 2 Stephanie Nonas , Anna A Birukova , Panfeng Fu , Jungjie Xing , Santipongse Chatchavalvanich , 3 4 2 2 Valery N Bochkov , Norbert Leitinger , Joe GN Garcia and Konstantin G Birukov 1Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA 2Department of Medicine, University of Chicago, 5801 South Ellis St, Chicago, IL 60637, USA 3Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria 4Cardiovascular Research Center, University of Virginia, 415 Lane Rd, Charlottesville, VA 22908, USA Corresponding author: Konstantin G Birukov, kbirukov@ Received: 7 Aug 2007 Revisions requested: 13 Sep 2007 Revisions received: 3 Jan 2008 Accepted: 24 Jan 2008 Published: 24 Jan 2008 Critical Care 2008, 12:R27 (doi:10.1186/cc6805) This article is online at: /content/12/1/R27 © 2008 Nonas et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background Mechanical ventilation at high tidal volume (HTV) Bronchoalveolar lav