palladium(ii) complexes of ns donor ligands derived from steroidal thiosemicarbazones as antibacterial agentsns捐赠者的钯(ii)配合物配体来源于甾族的thiosemicarbazones抗菌药物.pdf

Molecules 2010, 15, 4784-4791; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Communication Palladium(II) Complexes of NS Donor Ligands Derived from Steroidal Thiosemicarbazones as Antibacterial Agents Abdullah M. Asiri 1,2 and Salman A. Khan 1,* 1 Chemistry Department, Faculty of Science, King Abdul Aziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia 2 The Center of Excellence for Advanced Materials, King Abdul Aziz University, Jeddah 21589, P.O. Box 80203, Saudi Arabia * Author to whom correspondence should be addressed; E-Mail: sahmad_phd@yahoo.co.in. Received: 13 May 2010; in revised form: 28 May 2010 / Accepted: 9 June 2010 / Published: 8 July 2010 Abstract: We have investigated the antibacterial activity of some new steroidal thiosemicarbazones and their Pd(II) metal complexes were prepared by the reaction of the thiosemicarbazones with [Pd(DMSO) Cl ]. The steroidal thiosemicarbazones were 2 2 prepared by the reaction of thiosemicarbazides with a steroidal ketone. The structures of these compounds were elucidated by IR, 1H-NMR, 13C-NMR, FAB mass spectroscopic methods, elemental analyses and TGA analysis. The antibacterial activity of these compounds were tested in vitro by the disk diffusion assay against two Gram-positive and two Gram-negative bacteria. The results showed that steroidal complexes are better inhibitor