pellitorine, a potential anti-cancer lead compound against hl60 and mct-7 cell lines and microbial transformation of piperine from piper nigrumpellitorine,潜在的抗癌先导化合物对hl60和mct-7细胞系和微生物转换来自piper初步的胡椒碱.pdfVIP

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pellitorine, a potential anti-cancer lead compound against hl60 and mct-7 cell lines and microbial transformation of piperine from piper nigrumpellitorine,潜在的抗癌先导化合物对hl60和mct-7细胞系和微生物转换来自piper初步的胡椒碱.pdf

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pellitorine, a potential anti-cancer lead compound against hl60 and mct-7 cell lines and microbial transformation of piperine from piper nigrumpellitorine,潜在的抗癌先导化合物对hl60和mct-7细胞系和微生物转换来自piper初步的胡椒碱

Molecules 2010, 15, 2398-2404; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Pellitorine, a Potential Anti-Cancer Lead Compound against HL60 and MCT-7 Cell Lines and Microbial Transformation of Piperine from Piper Nigrum Gwendoline Cheng Lian Ee 1,*, Chyi Meei Lim 1, Mawardi Rahmani 1, Khozirah Shaari 1 and 2 Choon Fah Joseph Bong 1 Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia 2 Department of Crop Science, Faculty of Agriculture Food Sciences, Universiti Putra Malaysia Bintulu Campus, 97008, Bintulu, Sarawak, Malaysia ∗ Author to whom correspondence should be addressed; E-Mail: gwen@.my; Tel.: +60-389-466785. Received: 12 January 2010; in revised form: 9 March 2010 / Accepted: 18 March 2010 / Published: 5 April 2010 Abstract: Pellitorine (1), which was isolated from the roots of Piper nigrum , showed strong cytotoxic activities against HL60 and MCT-7 cell lines. Microbial transformation of piperine (2) gave a new compound 5-[3,4-(methylenedioxy)phenyl]-pent-2-ene piperidine (3). Two other alkaloids were also found from Piper nigrum. They are (E)-1-[3’,4’- (methylenedioxy)cinnamoyl]piperidine (4) and 2,4-tetradecadienoic acid isobutyl amide (5). These compounds were isolated using chromatographic methods and their structures were elucidated using MS, IR and NMR techniques. Keywords: Piper nigrum ; pellitorine; alkaloids; cyto