原创力文档pharmacokinetic comparability of prolastin？-c to prolastin？ in alpha1-antitrypsin deficiency a randomized study药代动力学的可比性prolastin - c prolastin alpha1-antitrypsin缺乏随机研究.pdfVIP
- 1、本文档共11页，可阅读全部内容。
- 2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
- 3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
pharmacokinetic comparability of prolastin？-c to prolastin？ in alpha1-antitrypsin deficiency a randomized study药代动力学的可比性prolastin - c prolastin alpha1-antitrypsin缺乏随机研究
Stocks et al. BMC Clinical Pharmacology 2010, 10:13
/1472-6904/10/13
RESEARCH ARTICLE Open Access
Pharmacokinetic comparability of Prolastin®-C to
Prolastin® in alpha1-antitrypsin deficiency: a
randomized study
1* 2 3 4 5
James M Stocks , Mark L Brantly , Laurene Wang-Smith , Michael A Campos , Kenneth R Chapman ,
Friedrich Kueppers6 7 8 9
, Robert A Sandhaus , Charlie Strange , Gerard Turino
Abstract
Background: Alpha -antitrypsin (AAT) deficiency is characterized by low blood levels of alpha -proteinase inhibitor
1 1
(alpha -PI) and may lead to emphysema. Alpha -PI protects pulmonary tissue from damage caused by the action
1 1
of proteolytic enzymes. Augmentation therapy with Prolastin® (Alpha1-Proteinase Inhibitor [Human]) to increase the
levels of alpha1-PI has been used to treat individuals with AAT deficiency for over 20 years. Modifications to the
Prolastin manufacturing process, incorporating additional purification and pathogen-reduction steps, have led to
the development of an alpha -PI product, designated Prolastin®-C (Alpha -Proteinase inhibitor [Human]). The
1 1
pharmacokinetic comparability of Prolastin-C to Prolastin was assessed in subjects with AAT deficiency.
Methods: In total, 24 subjects were randomized to receive 60 mg/kg of functionally active Prolastin-C or Prolastin
by weekly intravenous infusion for 8 weeks before crossover to the
您可能关注的文档
- patenting inventions arising from biological research申请专利的发明源自于生物研究.pdf
- pathogenesis of lassa fever拉沙热的发病机理.pdf
- patch testing in non-immediate drug eruptions在非直接子项药物爆发补丁测试.pdf
- pathogenesis of hepatitis c during pregnancy and childhood怀孕期间的丙型肝炎发病机理和童年.pdf
- pathogenesis of tendinopathies inflammation or degeneration病理病变的炎症或变性.pdf
- pathogenesis of noroviruses, emerging rna viruses诺瓦克病毒的发病机理,新兴rna病毒.pdf
- pathogenesis of peroxisomal deficiency disorders (zellweger syndrome) may be mediated by misregulation of the gabaergic system via the diazepam binding inhibitor缺过氧化物酶病症的发病机理(齐薇格综合征)可能由misregulation gaba ergic系统通过安定抑制剂具有约束力.pdf
- pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis b a case report病理性股骨骨折由于骨软化与阿德福伟治疗乙型肝炎病例报告.pdf
- pathogenicity island cag, vaca and is605 genotypes in mexican strains of helicobacter pylori associated with peptic ulcers致病性岛cag,vaca is605基因型在墨西哥株幽门螺杆菌相关的消化性溃疡.pdf
- pathogenic effect of interleukin-17a in induction of sj？gren's syndrome-like disease using adenovirus-mediated gene transfer致病性的影响interleukin-17a感应sj gren使用adenovirus-mediated基因转移症状的疾病.pdf
- installation procedures for emc use onlyvplex安装程序仅使用.pdf
- 街头小掌柜推荐.pdf
- 【课件】全等三角形及其性质+课件+人教版（2024）八年级数学上册+.pptx
- 2024-2025学年选调生考试模考模拟试题往年题考附答案详解.docx
- 说明成果csc 108h1 ut大一as winter 2015 am.pdf
- 河南省金太阳2024-2025学年高二下学期6月百万大联考语文试卷（含答案）.pdf
- 河南省金太阳2024-2025学年高二下学期6月百万大联考生物学试卷（含答案）.pdf
- 河南省金太阳2024-2025学年高二下学期6月百万大联考英语试卷（含答案）.pdf
- 河南省金太阳2024-2025学年高二下学期6月百万大联考思想政治试卷（含答案）.pdf
- 山西省阳泉市2024—2025学年七年级第二学期期末考试英语试卷（含答案）.pdf
文档评论（0）