photodynamic therapy with hypericin improved by targeting hsp90 associated proteins光动力治疗与金丝桃素一半寿命提高了目标相关的蛋白质.pdfVIP

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photodynamic therapy with hypericin improved by targeting hsp90 associated proteins光动力治疗与金丝桃素一半寿命提高了目标相关的蛋白质.pdf

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photodynamic therapy with hypericin improved by targeting hsp90 associated proteins光动力治疗与金丝桃素一半寿命提高了目标相关的蛋白质

Pharmaceuticals 2011, 4, 1488-1502; doi:10.3390/ph4111488 OPEN ACCESS Pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Article Photodynamic Therapy with Hypericin Improved by Targeting HSP90 Associated Proteins Peter Solár 1, Mária Chytilová 1, Zuzana Solárová 2, Ján Mojžiš 3, Peter Ferenc 1 and Peter Fedoročko 1,* 1 Laboratory of Cell Biology, Institute of Biology and Ecology, Faculty of Sciences, P.J. Šafárik University, 040 01 Košice, Slovak Republic; E-Mails: peter.solar@upjs.sk (P.S.); mariachytilova@ (M.C.); peter.ferenc@upjs.sk (P.F.) 2 Geriatric Nursing Clinic, Faculty of Medicine, P.J. Šafárik University, 040 01 Košice, Slovak Republic; E-Mail: zuzana.solarova@upjs.sk 3 Department of Pharmacology, Faculty of Medicine, P.J. Šafárik University,040 01 Košice, Slovak Republic; E-Mail: jan.mojzis@upjs.sk * Author to whom correspondence should be addressed; E-Mail: peter.fedorocko@upjs.sk; Tel.: +421-55-234-1182; Fax: +421-55-622-2124. Received: 1 September 2011; in revised form: 1 November 2011 / Accepted: 7 November 2011 / Published: 10 November 2011 Abstract: In this study we have focused on the response of SKBR-3 cells to both single 17-DMAG treatment as well as its combination with photodynamic therapy with hypericin. Low concentrations of 17-DMAG without any effect on survival of SKBR-3 cells significantly reduced metabolic activity, viability and cell number when combined with photodynamic therapy with hypericin. Moreover, IC10 concentation of 17-DMAG resulted in significant i