postnatal exposure to pcb 153 and pcb 180, but not to pcb 52, produces changes in activity level and stimulus control in outbred male wistar kyoto rats产后暴露于153年和180 pcb印刷电路板,而不是52岁的pcb生产活动水平的变化和刺激控制在远男性纯种京都的老鼠.pdfVIP

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postnatal exposure to pcb 153 and pcb 180, but not to pcb 52, produces changes in activity level and stimulus control in outbred male wistar kyoto rats产后暴露于153年和180 pcb印刷电路板,而不是52岁的pcb生产活动水平的变化和刺激控制在远男性纯种京都的老鼠.pdf

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postnatal exposure to pcb 153 and pcb 180, but not to pcb 52, produces changes in activity level and stimulus control in outbred male wistar kyoto rats产后暴露于153年和180 pcb印刷电路板,而不是52岁的pcb生产活动水平的变化和刺激控制在远男性纯种京都的老鼠

Johansen et al. Behavioral and Brain Functions 2011, 7:18 /content/7/1/18 RESEARCH Open Access Postnatal exposure to PCB 153 and PCB 180, but not to PCB 52, produces changes in activity level and stimulus control in outbred male Wistar Kyoto rats 1,3* 4 2 5 2 1 Espen Borgå Johansen , Monica Knoff , Frode Fonnum , Per Leines Lausund , S Ivar Walaas , Grete Wøien and Terje Sagvolden 1 Abstract Background: Polychlorinated biphenyls (PCBs) are a class of organic compounds that bioaccumulate due to their chemical stability and lipophilic properties. Humans are prenatally exposed via trans-placental transfer, through breast milk as infants, and through fish, seafood and fatty foods as adolescents and adults. Exposure has several reported effects ranging from developmental abnormalities to cognitive and motor deficiencies. In the present study, three experimental groups of rats were orally exposed to PCBs typically found in human breast milk and then behaviorally tested for changes in measures of stimulus control (percentage lever-presses on the reinforcer- producing lever), activity level (responses with IRTs 0.67 s), and responses with short IRTs ( 0.67 s). Methods: Male offspring from Wistar Kyoto (WKY/NTac) dams purchased pregnant from Taconic Farms (Germantown, NY) were orally given PCB at around postnatal day 8, 14, and 20 at a dose of 10 mg/kg body weight at each exposure. Three experimental groups were exposed either to PCB 52, PCB 153, or PCB 180. A fourth group fed corn oil only served as controls. From postnatal day 25, for 33 days, the animals were tested for behavioral changes using an operant procedure. Results: PCB exposure did not produce behavioral c