plasma srage enables prediction of acute lung injury after cardiac surgery in children等离子体srage使儿童心脏手术后急性肺损伤的预测.pdfVIP

Liu et al. Critical Care 2012, 16:R91 /content/16/3/R91 RESEARCH Open Access Plasma sRAGE enables prediction of acute lung injury after cardiac surgery in children 1 2 1 1 1 1 1 1* XiWang Liu , QiXing Chen , ShanShan Shi , Zhuo Shi , Ru Lin , LinHua Tan , JianGen Yu , Qiang Shu and XiangMing Fang2* Abstract Introduction: Acute lung injury (ALI) after cardiac surgery is associated with a high postoperative morbidity and mortality, but few predictors are known for the occurrence of the complication. This study evaluated whether elevated plasma levels of soluble receptor for advanced glycation end products (sRAGE) and S100A12 reflected impaired lung function in infants and young children after cardiac surgery necessitating cardiopulmonary bypass (CPB). Methods: Consecutive children younger than 3 years after cardiac surgery were prospectively enrolled and assigned to ALI and non-ALI groups, according to the American-European Consensus Criteria. Plasma concentrations of sRAGE and S100A12 were measured at baseline, before, and immediately after CPB, as well as 1 hour, 12 hours, and 24 hours after operation. Results: Fifty-eight patients were enrolled and 16 (27.6%) developed postoperative ALI. Plasma sRAGE and S100A12 levels increased immediately after CPB and remained significantly higher in the ALI group even 24 hour after operation (P 0.01). In addition, a one-way MANOVA revealed that the overall sRAGE and S100A12 levels were higher in the ALI group than in the non-ALI group immediately after CPB (P 0.001). The multivariate logistic regression analysis showed that the plasma sRAGE level immediately after CPB was an independent predictor for postoperative ALI (OR, 1