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phenotypic and transcriptional response to selection for alcohol sensitivity in drosophila melanogaster表型和转录反应选择对酒精敏感的黑腹果蝇.pdf

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phenotypic and transcriptional response to selection for alcohol sensitivity in drosophila melanogaster表型和转录反应选择对酒精敏感的黑腹果蝇

Volume 8, Issue 10, Article R231Morozovaet al.2007 Open Access Research Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster Tatiana V Morozova*†‡, Robert RH Anholt*†§ and Trudy FC Mackay†§ Addresses: *Department of Zoology, North Carolina State University, Raleigh, NC 27695, USA. †WM Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695, USA. ‡Institute of Molecular Genetics RAS, Kurchatov Square, Moscow 123182, Russia. §Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA. Correspondence: Trudy FC Mackay. Email: trudy_mackay@ Published: 31 October 2007 Received: 1 May 2007 Revised: 31 July 2007 Genome Biology 2007, 8:R231 (doi:10.1186/gb-2007-8-10-r231) Accepted: 31 October 2007 The electronic version of this article is the complete one and can be found online at /2007/8/10/R231 © 2007 Morozova et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. orthologs./pGenetics of alcohol sensitivityant to ethanol exposure has been used topGene-expression profiling combined with selection for genetically divergent itDrosophila /itlines either highly sensitividentify candidate genes that affect alcohol sensitivity, including 23 novel genes that have humane or resist- Abstract Background: Alcoholism is a complex disorder determined by interactions between genetic and environ