原创力文档plasma thioredoxin levels during post-cardiac arrest syndrome relationship with severity and outcome等离子体硫氧还蛋白水平在post-cardiac逮捕综合症与严重程度和结果之间的关系.pdfVIP
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plasma thioredoxin levels during post-cardiac arrest syndrome relationship with severity and outcome等离子体硫氧还蛋白水平在post-cardiac逮捕综合症与严重程度和结果之间的关系
Mongardon et al. Critical Care 2013, 17:R18
/content/17/1/R18
RESEARCH Open Access
Plasma thioredoxin levels during post-cardiac
arrest syndrome: relationship with severity and
outcome
1,2* 1,2 2,3 4 5
Nicolas Mongardon , Virginie Lemiale , Didier Borderie , Anne Burke-Gaffney , Sébastien Perbet ,
Nathalie Marin1,2, Julien Charpentier1,2, Frédéric Pène1,2,6, Jean-Daniel Chiche1,2,6, Jean-Paul Mira1,2,6 and
Alain Cariou1,2,7
Abstract
Introduction: Despite experimental evidence, clinical demonstration of acute state of oxidative stress and
inflammation during post-cardiac arrest syndrome is lacking. Plasma level of thioredoxin (TRX), a redox-active
protein induced under conditions of oxidative stress and inflammation, is increased in various critical care
conditions. We determined plasma TRX concentrations after cardiac arrest and assessed relationships with severity
and outcome.
Methods: Retrospective study of consecutive patients admitted to a single academic intensive care unit (ICU) for
out-of-hospital cardiac arrest (between July 2006 and March 2008). Plasma levels of TRX were measured at
admission, day (D) 1, 2 and 3.
Results: Of 176 patients included, median TRX values measured in ICU survivors and non-survivors were, respectively:
22 ng/mL (7.8 to 77) vs. 72.4 (21.9 to 117.9) at admission (P 0.001); 5.9 (3.5 to 25.5) vs. 23.2 (5.8 to 81.4) at D1 (P =
0.003); 10.8 (3.6 to 50.8) vs. 11.7 (4.5 to 66.4) at D2 (P = 0.22); and 16.7 (5.3 to 68.3) vs. 17 (4.3 to 62.9) at D3 (P = 0.96).
Patients dying within 24 hours had significantly (P 0.001) higher TRX levels (118.6 ng/mL (94.8 to 280)) than those
who died after 24 hours or survived (50.8 (13.9 to 95.7) and 22 (7.8 to 7
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