原创力文档post-synapse model cell for synaptic glutamate receptor (glur)-based biosensing strategy and engineering to maximize ligand-gated ion-flux achieving high signal-to-noise ratiopost-synapse模型细胞突触谷氨酸受体(glur)的若战略和工程最大化ligand-gated离子流实现高信噪比.pdfVIP
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post-synapse model cell for synaptic glutamate receptor (glur)-based biosensing strategy and engineering to maximize ligand-gated ion-flux achieving high signal-to-noise ratiopost-synapse模型细胞突触谷氨酸受体(glur)的若战略和工程最大化ligand-gated离子流实现高信噪比
Sensors 2012, 12, 1035-1041; doi:10.3390/s120101035
OPEN ACCESS
sensors
ISSN 1424-8220
/journal/sensors
Article
Post-Synapse Model Cell for Synaptic Glutamate Receptor
(GluR)-Based Biosensing: Strategy and Engineering to Maximize
Ligand-Gated Ion-Flux Achieving High Signal-to-Noise Ratio
1 2 1 2
Akito Tateishi , Sarah K. Coleman , Satoshi Migita , Kari Keinänen and
Tetsuya Haruyama 1,*
1 Department of Biological Functions and Engineering, Kyushu Institute of Technology,
Kitakyushu Science and Research Park, Fukuoka, 808-0196, Japan;
E-Mails: tateishi-akito@edu.life.kyutech.ac.jp (A.T.); migita.met@tmd.ac.jp (S.M.)
2 Department of Biosciences, Division of Biochemistry and Biotechnology, Viikki Biocenter,
University of Helsinki, Helsinki, Finland; E-Mails: sarah.coleman@helsinki.fi (S.K.C.);
kari.keinanen@helsinki.fi (K.K.)
* Author to whom correspondence should be addressed; E-Mail: haruyama@life.kyutech.ac.jp;
Tel./Fax: +81-93-695-6065.
Received: 21 December 2011; in revised form: 13 January 2012 / Accepted: 13 January 2012 /
Published: 18 January 2012
Abstract: Cell-based biosensing is a “smart” way to obtain efficacy-information on the
effect of applied chemical on cellular biological cascade. We have proposed an engineered
post-synapse model cell-based biosensors to investigate the effects of chemicals on
ionotropic glutamate receptor (GluR), which is a focus of attention as a molecular target
for
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