predictors for diabetic retinopathy in normoalbuminuric people with type 2 diabetes mellitus预测normoalbuminuric糖尿病性视网膜病变的2型糖尿病患者.pdfVIP

Ra et al. Diabetology Metabolic Syndrome 2012, 4:29 DIABETOLOGY /content/4/1/29 METABOLIC SYNDROME RESEARCH Open Access Predictors for diabetic retinopathy in normoalbuminuric people with type 2 diabetes mellitus 1 2 2 2 2 2 2 Ho Ra , Ji Han Yoo , Woo Ho Ban , Ho Cheol Song , Seong Su Lee , Sung Rae Kim , Soon Jib Yoo , Yong-Soo Kim2, Euy Jin Choi2 and Yong Kyun Kim2,3* Abstract Background: Previous studies have reported that microalbuminuria is an independent risk factor for the prevalence of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (DM). For this reason, the clinical significance of DR in normoalbuminuric type 2 DM patients may be overlooked. The aim of this study was to investigate the prevalence of DR and predictors for DR in normoalbuminuric patients with type 2 DM. Methods: A total 310 patients with type 2 DM and normoalbuminuria, who were referred to the Department of Ophthalmology for screening of DR were included in this study. DR was clinically graded according to the International Clinical Diabetic Retinopathy guidelines. The urinary albumin excretion rate (UAER) was assessed via 24-hour urine collection and measured by immunoturbidimetric assay. Normoalbuminuria was defined as a UAER 20 μg/min in 2 out of 3 consecutive tests taken within 2–3 months. Results: DR of any grade was present in 64/310 (20.7 %) patients. Mild non-proliferative diabetic retinopathy (NPDR) was most prevalent in patients with DR of any grade (36/64, 56 %). The duration of d