protein-bound uremic toxins new insight from clinical studies从临床研究蛋白结合的尿毒症毒素新的见解.pdfVIP

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protein-bound uremic toxins new insight from clinical studies从临床研究蛋白结合的尿毒症毒素新的见解.pdf

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protein-bound uremic toxins new insight from clinical studies从临床研究蛋白结合的尿毒症毒素新的见解

Toxins 2011, 3, 911-919; doi:10.3390/toxins3070911 OPEN ACCESS toxins ISSN 2072-6651 /journal/toxins Article Protein-Bound Uremic Toxins: New Insight from Clinical Studies Sophie Liabeuf 1,2,3, Tilman B. Drüeke 1 and Ziad A. Massy 1,2,3,4,* 1 INSERM ERI-12 (EA 4292), Amiens 80000, France; E-Mails: liabeuf.sophie@chu-amiens.fr (S.L.); tilman.drueke@inserm.fr (T.B.D.) 2 Clinical Research Centre-Division of Clinical Pharmacology, Amiens University Hospital, Amiens 80000, France 3 The Jules Verne University of Picardy, Amiens 80000, France 4 Division of Nephrology, Amiens University Hospital, Amiens 80000, France * Author to whom correspondence should be addressed; E-Mail: massy@u-picardie.fr; Tel.: +33-322-455788; Fax: +33-322-455660. Received: 29 April 2011; in revised form: 28 June 2011 / Accepted: 5 July 2011 / Published: 20 July 2011 Abstract : The uremic syndrome is attributed to the progressive retention of a large number of compounds which, under normal conditions, are excreted by healthy kidneys. The compounds are called uremic toxins when they interact negatively with biological functions. The present review focuses on a specific class of molecules, namely the family of protein-bound uremic toxins. Recent experimental studies have shown that protein-bound toxins are involved not only in the progression of chronic kidney disease (CKD), but also in the generation and aggravation of cardiovasc