proteinase-3 as the major autoantigen of c-anca is strongly expressed in lung tissue of patients with wegeners granulomatosisproteinase-3 c-anca强烈的主要自身抗原表达韦格纳肉芽肿病的患者的肺组织.pdfVIP

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proteinase-3 as the major autoantigen of c-anca is strongly expressed in lung tissue of patients with wegeners granulomatosisproteinase-3 c-anca强烈的主要自身抗原表达韦格纳肉芽肿病的患者的肺组织.pdf

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proteinase-3 as the major autoantigen of c-anca is strongly expressed in lung tissue of patients with wegeners granulomatosisproteinase-3 c-anca强烈的主要自身抗原表达韦格纳肉芽肿病的患者的肺组织

Available online /content/4/3/220 Research article Proteinase-3 as the major autoantigen of c-ANCA is strongly expressed in lung tissue of patients with Wegener’s granulomatosis 1 1 2 2 2 Holger Brockmann , Andreas Schwarting , Jörg Kriegsmann , Peter Petrow , Andreas Gaumann , Klaus-Michael Müller3, Peter Robert Galle1 and Werner Mayet4 1Department of Medicine, University of Mainz, Mainz, Germany 2Institute of Pathology, University of Mainz, Mainz, Germany 3Institute of Pathology, Professional Associations Hospital, Ruhr-University, Bochum, Germany 4Center of Internal Medicine, Nordwest Hospital, Sanderbusch, Germany Correspondence: Werner J Mayet, MD, Center of Internal Medicine, Nordwest Hospital, Sanderbusch, Germany. Tel: +49 4422 801101; fax: +49 4422 801130; e-mail: mayet@sanderbusch.de Received: 23 April 2001 Arthritis Res 2002, 4:220-225 Revisions requested: 1 June 2001 This article may contain supplementary data which can only be found Revisions received: 17 December 2001 online at /content/4/3/220 Accepted: 4 January 2002 © 2002 Brockmann et al., licensee BioMed Central Ltd Published: 27 March 2002 (Print ISSN 1465-9905; Online ISSN 1465-9913) Abstract Proteinase-3 (PR-3) is a neutral serine proteinase present in azurophil granules of human polymorphonuclear leukocytes and serves as the major target antigen of antineutrophil cytoplasmic antibodies with a cytoplasmic staining pattern (c-ANCA) in Wegener’s granulomatosis (WG). The WG