原创力文档prothrombin complex concentrate in surgical patients retrospective evaluation of vitamin k antagonist reversal and treatment of severe bleeding凝血酶原复杂集中在手术患者回顾性评价维生素k拮抗剂逆转和治疗严重的出血.pdfVIP
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prothrombin complex concentrate in surgical patients retrospective evaluation of vitamin k antagonist reversal and treatment of severe bleeding凝血酶原复杂集中在手术患者回顾性评价维生素k拮抗剂逆转和治疗严重的出血
Available online /content/13/6/R191
Vol 13 No 6 Open Access
Research
Prothrombin complex concentrate in surgical patients:
retrospective evaluation of vitamin K antagonist reversal and
treatment of severe bleeding
Kerstin S Schick, Jan M Fertmann, Karl-Walter Jauch and Johannes N Hoffmann
Department of Surgery, University of Munich - Großhadern, Marchioninistrasse 15 81377 Munich, Germany
Corresponding author: Johannes N Hoffmann, johannes.hoffmann@med.uni-muenchen.de
Received: 8 Jul 2009 Revisions requested: 27 Aug 2009 Revisions received: 13 Nov 2009 Accepted: 30 Nov 2009 Published: 30 Nov 2009
Critical Care 2009, 13:R191 (doi:10.1186/cc8186)
This article is online at: /content/13/6/R191
© 2009 Schick et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction Prothrombin complex concentrates are prothrombin complex concentrate infusion (median dose 1500
recommended for rapid reversal of vitamin K anticoagulants. As IU; lower quartile 1,000, upper quartile 2,000). No major
they normalize levels of vitamin K dependent clotting factors and bleeding was observed during surgery after prothrombin
re-establish hemostasis, they may also be used as adjunctive complex concentrate administration. Only one patient received
therapy in patients with major bleeding. The aim of this study platelets and red blood cell transfusion after prot
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