relationship between exposure to vector bites and antibody responses to mosquito salivary gland extracts接触向量之间的关系咬蚊子唾液腺提取物和抗体反应.pdfVIP

Relationship between Exposure to Vector Bites and Antibody Responses to Mosquito Salivary Gland Extracts 1. ´ 1. 2 1 ´ 3 ´ ´ Albin Fontaine , Aurelie Pascual , Eve Orlandi-Pradines , Ibrahima Diouf , Franck Remoue , Frederic ` 2 ¨ 1 1,4 1 Pages , Thierry Fusaı , Christophe Rogier , Lionel Almeras * ´ ´ ´ ´ ´ 1 Unite de Parasitologie, Antenne Marseille de l’Institut de Recherche Biomedicale des Armees (IRBA), Marseille, France, 2 Unite d’Entomologie Medicale, Antenne ´ ´ ´ Marseille de l’Institut de Recherche Biomedicale des Armees (IRBA), Marseille, France, 3 Caracterisation des Populations de vecteurs, Institut de Recherche pour le ´ Developpement (IRD), Montpellier, France, 4 Institut Pasteur de Madagascar, Antananarivo, Madagascar Abstract Mosquito-borne diseases are major health problems worldwide. Serological responses to mosquito saliva proteins may be useful in estimating individual exposure to bites from mosquitoes transmitting these diseases. However, the relationships between the levels of these IgG responses and mosquito density as well as IgG response specificity at the genus and/or species level need to be clarified prior to develop new immunological markers to assess human/vector contact. To this end, a kinetic study of antibody levels against several mosquito