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Algorithms for Molecular Biology BioMed Central Research Open Access Reconstructing protein structure from solvent exposure using tabu search 1 2 1 Martin Paluszewski* , Thomas Hamelryck and Pawel Winter Address: 1Department of Computer Science, University of Copenhagen, Universitetsparken 1, 2100 Copenhagen, Denmark and 2Bioinformatics Center, Institute of Molecular Biology, University of Copenhagen, Universitetsparken 15 building 10, 2100 Copenhagen, Denmark Email: Martin Paluszewski* - palu@diku.dk; Thomas Hamelryck - thamelry@binf.ku.dk; Pawel Winter - pawel@diku.dk * Corresponding author Published: 27 October 2006 Received: 30 March 2006 Accepted: 27 October 2006 Algorithms for Molecular Biology 2006, 1:20 doi:10.1186/1748-7188-1-20 This article is available from: /content/1/1/20 © 2006 Paluszewski et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: A new, promising solvent exposure measure, called half-sphere-exposure (HSE), has recently been proposed. Here, we study the reconstruction of a proteins Cα trace solely from structure-derived HSE information. This problem is of relevance for de novo structure prediction using predicted HSE measure. For comparison, we also consider the well-established contact number (CN)