residential proximity to industrial combustion facilities and risk of non-hodgkin lymphoma a case--control study住宅靠近工业燃烧设备和非霍奇金淋巴瘤的风险案例,对照研究.pdfVIP

Pronk et al. Environmental Health 2013, 12:20 /content/12/1/20 RESEARCH Open Access Residential proximity to industrial combustion facilities and risk of non-Hodgkin lymphoma: a case–control study 1,2 3 4,5 6 1 7 Anjoeka Pronk , John R Nuckols , Anneclaire J De Roos , Matthew Airola , Joanne S Colt , James R Cerhan , 1 8 9 1 10 1,11* Lindsay Morton , Wendy Cozen , Richard Severson , Aaron Blair , David Cleverly and Mary H Ward Abstract Background: Residence near municipal solid waste incinerators, a major historical source of dioxin emissions, has been associated with increased risk of non-Hodgkin lymphoma (NHL) in European studies. The aim of our study was to evaluate residence near industrial combustion facilities and estimates of dioxin emissions in relation to NHL risk in the United States. Methods: We conducted a population-based case–control study of NHL (1998–2000) in four National Cancer Institute-Surveillance Epidemiology and End Results centers (Detroit, Iowa, Los Angeles, Seattle). Residential histories 15 years before diagnosis (similar date for controls) were linked to an Environmental Protection Agency database of dioxin-emitting facilities for 969 cases and 749 controls. We evaluated proximity (3 and 5 km) to 10 facility types that accounted for 85% of U.S. emissions and a distance-weighted average emission index (AEI [ng toxic equivalency quotient (TEQ)/year]). Results: Proximity to any dioxin-emitting facility was not associated with NHL risk (3 km OR = 1.0, 95% CI 0.8-1.3). Risk was elevated for residence near ce