relaxin and β-estradiol modulate targeted matrix degradation in specific synovial joint fibrocartilages progesterone prevents matrix loss松弛素和β-estradiol调节目标矩阵退化在特定的滑膜关节纤维软骨孕酮预防矩阵损失.pdfVIP

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relaxin and β-estradiol modulate targeted matrix degradation in specific synovial joint fibrocartilages progesterone prevents matrix loss松弛素和β-estradiol调节目标矩阵退化在特定的滑膜关节纤维软骨孕酮预防矩阵损失.pdf

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relaxin and β-estradiol modulate targeted matrix degradation in specific synovial joint fibrocartilages progesterone prevents matrix loss松弛素和β-estradiol调节目标矩阵退化在特定的滑膜关节纤维软骨孕酮预防矩阵损失

Available online /content/8/4/R98 Vol 8 No 4 Open Access Research article Relaxin and β-estradiol modulate targeted matrix degradation in specific synovial joint fibrocartilages: progesterone prevents matrix loss Gihan Hashem, Qin Zhang, Takayuki Hayami, Jean Chen, Wei Wang and Sunil Kapila Department of Orthodontics and Pediatric Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI 48109-1078, USA Corresponding author: Sunil Kapila, skapila@ Received: 21 Mar 2006 Revisions requested: 10 May 2006 Revisions received: 17 May 2006 Accepted: 25 May 2006 Published: 19 Jun 2006 Arthritis Research Therapy 2006, 8:R98 (doi:10.1186/ar1978) This article is online at: /content/8/4/R98 © 2006 Hashem et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Relaxin, a 6-kDa polypeptide hormone, is a potent mediator of subcutaneous implantation of osmotic pumps containing relaxin matrix turnover and contributes to the loss of collagen and (23.3 µg/kg) or saline. Tissues were retrieved 4 days later and glycosaminoglycans (GAGs) from reproductive tissues, analyzed for GAG and collagen. Serum relaxin levels were including the fibrocartilaginous pubic symphysis of several assayed using enzyme-linked immunosorbent assay. Relaxin species. This effect is often potentiated by β-estradiol. We administration resulted in a 30-fold signi